Genetic linkage analysis of complex genetic traits by using affected sibling pairs

被引：41
|
作者：
Hauser, ER
机构：
[1] Duke Univ, Med Ctr, Dept Med, Med Genet Sect, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USA
[3] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
来源：
BIOMETRICS | 1998年 / 54卷 / 04期
关键词：
affected sibling pairs; complex diseases; genetic methods; genetics; identity by descent; linkage analysis;
D O I：
10.2307/2533653
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We provide an introduction to genetic linkage analysis. We discuss methods for the genetic analysis of common, complex disease such as diabetes, heart disease or hypertension. We describe the analysis of affected sibling pairs and discuss some of the challenges in applying these methods.
引用
下载
收藏
页码：1238 / 1246
页数：9
相关论文
共 50 条
  • [11] Multipoint linkage analysis of the pseudo-autosomal region using affected sibling pairs.
    Dupuis, J
    Van Eerdewegh, P
    AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) : A247 - A247
  • [12] Covariates in linkage analysis using sibling and cousin pairs
    Saccone, NL
    Rochberg, N
    Neuman, RJ
    Rice, JP
    GENETIC EPIDEMIOLOGY, 2001, 21 : S540 - S545
  • [13] Mixture models for linkage analysis of affected sibling pairs with covariates - "Reply to Olson"
    Devlin, B
    Bacanu, SA
    Jones, BL
    Roeder, K
    GENETIC EPIDEMIOLOGY, 2002, 23 (04) : 449 - 455
  • [14] MICROSATELLITES FOR LINKAGE ANALYSIS OF GENETIC-TRAITS
    HEARNE, CM
    GHOSH, S
    TODD, JA
    TRENDS IN GENETICS, 1992, 8 (08) : 288 - 294
  • [15] Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives
    Rohde, K
    Teare, MD
    Koref, MS
    AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (02) : 418 - 422
  • [16] Quantitative genetic analysis station for the genetic analysis of complex traits
    Chen GuoBo
    Zhu ZhiXiang
    Zhang FuTao
    Zhu Jun
    CHINESE SCIENCE BULLETIN, 2012, 57 (21): : 2721 - 2726
  • [17] Mixture models for linkage analysis of affected sibling pairs with covariates - "Reply to Olson" - "Rejoionder"
    Olson, JM
    GENETIC EPIDEMIOLOGY, 2002, 23 (04) : 456 - 457
  • [18] LINKAGE STRATEGIES FOR GENETICALLY COMPLEX TRAITS .2. THE POWER OF AFFECTED RELATIVE PAIRS
    RISCH, N
    AMERICAN JOURNAL OF HUMAN GENETICS, 1990, 46 (02) : 229 - 241
  • [19] Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
    Purcell, S
    Cherny, SS
    Sham, PC
    BIOINFORMATICS, 2003, 19 (01) : 149 - 150
  • [20] Genetic architecture reconciles linkage and association studies of complex traits
    Sidorenko, Julia
    Couvy-Duchesne, Baptiste
    Kemper, Kathryn E.
    Moen, Gunn-Helen
    Bhatta, Laxmi
    Asvold, Bjorn Olav
    Magi, Reedik
    Ani, Alireza
    Wang, Rujia
    Nolte, Ilja M.
    Gordon, Scott
    Hayward, Caroline
    Campbell, Archie
    Benjamin, Daniel J.
    Cesarini, David
    Evans, David M.
    Goddard, Michael E.
    Haley, Chris S.
    Porteous, David
    Medland, Sarah E.
    Martin, Nicholas G.
    Snieder, Harold
    Metspalu, Andres
    Hveem, Kristian
    Brumpton, Ben
    Visscher, Peter M.
    Yengo, Loic
    NATURE GENETICS, 2024, : 2352 - 2360
12345