Genetic linkage analysis of complex genetic traits by using affected sibling pairs

被引：41
|
作者：
Hauser, ER
机构：
[1] Duke Univ, Med Ctr, Dept Med, Med Genet Sect, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USA
[3] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
来源：
BIOMETRICS | 1998年 / 54卷 / 04期
关键词：
affected sibling pairs; complex diseases; genetic methods; genetics; identity by descent; linkage analysis;
D O I：
10.2307/2533653
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We provide an introduction to genetic linkage analysis. We discuss methods for the genetic analysis of common, complex disease such as diabetes, heart disease or hypertension. We describe the analysis of affected sibling pairs and discuss some of the challenges in applying these methods.
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页码：1238 / 1246
页数：9
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