Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae

被引：108
|
作者：
Depardieu, F [1 ]
Courvalin, P [1 ]
机构：
[1] Inst Pasteur, Unite Agents Antibacteriens, F-75724 Paris 15, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 01期
关键词：
D O I：
10.1128/AAC.45.1.319-323.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.
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收藏
页码：319 / 323
页数：5
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