Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides

被引：64

作者：

Misyurina, OY

Chipitsyna, EV

Finashutina, YP

Lazarev, VN

Akopian, TA

Savicheva, AM

Govorun, VM

机构：

[1] Russian Federat Minist Hlth, Res Inst Physicochem Med, Moscow 119992, Russia

[2] Lytech Ltd, Moscow, Russia

[3] Russian Acad Med Sci, DO Ott Res Inst Obstet & Gynaecol, St Petersburg, Russia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 04期

关键词：

D O I：

10.1128/AAC.48.4.1347-1349.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

For six clinical isolates of Chlamydia trachomatis, in vitro susceptibility to erythromycin, azithromycin, and josamycin has been determined. Four isolates were resistant to all the antibiotics and had the mutations A2058C and T2611C (Escherichia coli numbering) in the 23S rRNA gene. All the isolates had mixed populations of bacteria that did and did not carry 23S rRNA gene mutations.

引用

页码：1347 / 1349

页数：3

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