Sex-specific associations of maternal birthweight with offspring birthweight in the Omega study

Purpose: We investigated nonlinear and offspring sex specific associations of maternal birthweight (BW) with offspring BW among participants of the Omega study, a pregnancy cohort. Methods: Maternal BW was modeled as a continuous variable, linear spline and binary variable indicating low birthweight (LBW; <2500 vs. >= 2500 grams). Offspring BW was modeled as a continuous and binary variable in regression models. Nonlinearity was assessed using likelihood ratio tests (LRTs) in marginal linear spline models. Results: For every 100-gram increase of maternal BW, offspring BW increased by 22.29 (95% CI: 17.57, 27.02) or 23.41 (95% CI: 6.87, 39.96) grams among mothers with normal BW or born macrosomic, respectively, but not among LBW mothers (beta = -8.61 grams; 95% CI: -22.88, 5.65; LRT P-value =.0005). For every 100-gram increase in maternal BW, BW of male offspring increased 23.47 (95% CI: 16.75, 30.19) or 25.21 (95% CI: 4.35, 46.07) grams among mothers with normal BW or born macrosomic, respectively, whereas it decreased 31.39 grams (95% CI: -51.63, -11.15) among LBW mothers (LRT P-value <.0001). Corresponding increases in BW of female offspring (16-22 grams) did not differ among mothers with LBW, normal BW or macrosomia (LRT P-value =.9163). Conclusions: Maternal and offspring BW associations are evident among normal BW and macrosomic mothers. These associations differ by offspring sex. (C) 2017 Elsevier Inc. All rights reserved.