Prognostic Significance of p53 and KAI-1 Expression in Patients with Laryngeal Squamous Cell Carcinoma

被引：0
|
作者：
Re, Massimo [1 ]
Magliulo, Giuseppe [2 ]
Salvolini, Eleonora [3 ]
Orciani, Monia [3 ]
Gioacchini, Federico Maria [1 ]
Goteri, Gala [4 ]
Rubini, Corrado [4 ]
机构：
[1] Polytech Univ Marche, Dept Clin Sci Otorhinolaryngol, I-60126 Ancona, Italy
[2] Univ Roma La Sapienza, G Ferreri Dept Otorhinolaryngol, Rome, Italy
[3] Polytech Univ Marche, Dept Mol Pathol & Innovat Therapies Histol, I-60126 Ancona, Italy
[4] Polytech Univ Marche, Dept Neurosci Pathol Anat, I-60126 Ancona, Italy
来源：
ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY | 2010年 / 32卷 / 05期
关键词：
immunohistochemistry; KAI-1; larynx; p53; prognostic factors; squamous cell carcinoma; METASTASIS SUPPRESSOR; OVER-EXPRESSION; PANCREATIC-CANCER; LUNG-CANCER; CYCLIN D1; TUMOR; GENE; BCL-2; HEAD; SURVIVAL;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
OBJECTIVE: To examine the prognostic significance of the immunohistochemical expression of p53 and KAI-1 oncoproteins in patients with laryngeal squamous cell carcinoma. STUDY DESIGN: A retrospective evaluation was developed on 82 patients with primary laryngeal squamous cell carcinoma treated by primary surgery. For the immunohistochemical evaluation, formalin-fixed and paraffin-embedded tissue blocks from resection were used. Clinicopathologic data were correlated with the staining results. RESULTS: The results of the immunohistochemical examination showed a statistically significant relationship between down-regulation of KAI-1 protein expression, increase of the histologic grading, and primary tumors associated with lymph node metastases. On the other hand, no statistical correlation was evidenced between p53 up-regulation and clinicopathologic data or between the two markers. CONCLUSION: Our results suggest that KAI-1 may become an important biomarker that could help in selection of high-risk patients with laryngeal spumous cell carcinoma who may benefit from more aggressive therapy or chemoprevention. (Anal Quant Cytol Histol 2010;32:247-253)
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页码：247 / 253
页数：7
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