Ribavirin: Analytical determinations since the origin until today

被引：23

作者：

Bosch, M. Espinosa

Sanchez, A. J. Ruiz

Rojas, F. Sanchez

Ojeda, C. Bosch

机构：

[1] Univ Malaga, Fac Sci, Dept Analyt Chem, E-29071 Malaga, Spain

[2] Univ Hosp Virgen Rocio, Gen Hosp, Dept Pharm, Seville 41013, Spain

[3] Univ Malaga, Fac Sci, Dept Organ Chem, E-29071 Malaga, Spain

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2007年 / 45卷 / 02期

关键词：

ribavirin; review; pharmaceutical formulations; biological samples; antiviral therapy;

D O I：

10.1016/j.jpba.2007.06.004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ribavirin (RV) (1 -beta-D-ribofuranosyl- 1,2,4-triazole-3-carboxamide), is a synthetic purine nucleoside analog with a broad spectrum of antiviral activity. To better understand the mechanism of action of RV, as well as its pharmacokinetic characteristics, an assay that can allow specific, sensitive, and accurate measurement of RV in biologic samples is critical. In this way, diverse analytical methods have been established. In this work, we have recompiled these methods with the aim to present the different options for the RV determination. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：185 / 193

页数：9

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