Research and Application Progress of Paper-based Microfluidic Sample Preconcentration

Sample pretreatment is a key link in the whole process of analysis and detection. For samples whose original concentration is lower than the detection limit of analytical method, pre concentration technology is necessary, which is beneficial to improve the accuracy of the analytical method and expand the application range. However, conventional sample pre concentration technology is often cumbersome and depends on expensive equipment, resulting in the increased inspection time and cost. The paper-based microfluidic sample pre concentration technology is favored by domestic and foreign scholars for its easy preparation, low cost and high efficiency. This technology simplifies the operation process and reduces the detection cost. This paper focuses on the research and application progress of paper-based microfluidic sample preconcentration in recent years, including enrichment principle, paper-based material selection and device structure design, and the application of this technology. Finally, the development trend of this technology is prospected.