Genomic diversity of Clostridium difficile strains

被引：42

作者：

Janezic, Sandra ^{[1
]}

Rupnik, Maja ^{[1
,2
,3
]}

机构：

[1] Natl Lab Hlth Environm & Food, Maribor 2000, Slovenia

[2] Univ Maribor, Fac Med, Maribor 2000, Slovenia

[3] Ctr Excellence Integrated Approaches Chem & Biol, Ljubljana 1000, Slovenia

来源：

RESEARCH IN MICROBIOLOGY | 2015年 / 166卷 / 04期

关键词：

Clostridium difficile; Diversity; Toxinotyping; WGS; Clades; FIELD GEL-ELECTROPHORESIS; MOLECULAR TYPING METHODS; SEVERE-DISEASE; TOXIN PRODUCTION; VARIANT STRAIN; SPACER REGIONS; GENE SEQUENCE; S-LAYER; EPIDEMIC; EMERGENCE;

D O I：

10.1016/j.resmic.2015.02.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Approaches to exploring Clostridium difficile genomic diversity have ranged from molecular typing methods to use of comparative genome microarrays and whole genome sequence comparisons. The C. difficile population structure is clonal and distributed into six clades, which correlate well with MLST STs (multilocus sequence types) and PCR ribotypes. However, toxigenic strains and strains with increased virulence are distributed throughout several clades. Here we summarize studies on C. difficile genomic diversity, with emphasis on phylogenetic aspects, epidemiological aspect and variability of some virulence factors. (C) 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：353 / 360

页数：8

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