Antidiabetic principle from Eclipta prostrata

被引：0

作者：

Rahman, Mohammad S. ^{[1
]}

Rahman, Mohammed Z. ^{[2
]}

Begum, Bilkis ^{[3
]}

Chowdhury, Rasheduzzaman ^{[1
]}

Islam, Sk. Nazrul ^{[4
]}

Rashid, Mohammad A. ^{[1
]}

机构：

[1] Univ Dhaka, Fac Pharm, Dept Pharmaceut Chem, Dhaka 1000, Bangladesh

[2] Univ Asia Pacific, Dept Pharm, Dhaka 1209, Bangladesh

[3] Univ Dhaka, Fac Pharm, Dept Clin Pharm & Pharmacol, Dhaka 1000, Bangladesh

[4] Univ Dhaka, Inst Nutr & Food Sci, Dhaka 1000, Bangladesh

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2011年 / 30卷 / 08期

关键词：

Antidiabetic; Eclipta prostrata; Saponin; Eclalbasaponin; OLEANANE-TYPE; INSULIN-LIKE; STREPTOZOTOCIN; GLYCOSIDES; EXTRACT;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The methanol extract of the whole plant of Eclipta prostrata and one of its isolated compounds, eclalbasaponin II were administered to alloxan-induced diabetic rats for 28 and 7 consecutive days, respectively. During the study, a potent antidiabetic activity was observed. Blood sugar was significantly (p < 0.001) reduced by E. prostrata extract (300 mg/kg) and eclalbasaponin II (10 mg/kg), as compared to untreated diabetic rats. Analyses of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) showed no significant (p < 0.001) hepatotoxicity by E. prostrata extractive in alloxan-induced diabetic rats when compared to the diabetic control rats.

引用

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页码：1656 / 1660

页数：5

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