MAIT cell subtypes in multiple sclerosis

被引：13

作者：

Ammitzboll, Cecilie ^{[1
]}

von Essen, Marina R. ^{[1
]}

Chow, Helene Hojsgaard ^{[1
]}

McWilliam, Oskar ^{[1
]}

Hansen, Rikke Holm ^{[1
]}

Sellebjerg, Finn ^{[1
]}

机构：

[1] Univ Copenhagen, Rigshosp, Dept Neurol, Danish Multiple Sclerosis Ctr, Glostrup, Denmark

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 339卷

关键词：

INVARIANT T-CELLS; IMMUNOLOGY; EXPRESSION; IL-17; CNS;

D O I：

10.1016/j.jneuroim.2019.577117

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In patients with multiple sclerosis (MS) and healthy controls (HC) we studied circulating MALT cells and MAIT cell subtypes expressing CXCR3 and CCR6 by flow cytometry. Absolute numbers of MALT cells and specifically Tc17-like MAIT cells were lower in patients with primary progressive MS (PPMS) than in controls. Low numbers of Tc17-like MALT cells were associated with smoking and high concentrations of myelin basic protein in the cerebrospinal fluid. Treatment with alemtuzumab and dimethyl fumarate decreased MAIT cell frequencies. Altogether, we have identified specific MAIT cell subtypes related to PPMS, smoking and demyelination, and MAIT cell effects of MS therapies.

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页数：8

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