CD36 modulates proinflammatory cytokine responses to Plasmodium falciparum glycosylphosphatidylinositols and merozoites by dendritic cells
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作者:
Kumar, S.
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Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USAPenn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
Kumar, S.
[1
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Gowda, N. M.
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Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USAPenn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
Gowda, N. M.
[1
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Wu, X.
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Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USAPenn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
Wu, X.
[1
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Gowda, R. N.
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Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USAPenn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
Gowda, R. N.
[1
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Gowda, D. C.
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Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USAPenn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
Gowda, D. C.
[1
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[1] Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Milton S Hershey Med Ctr, Hershey, PA 17033 USA
Studies have shown that glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum activate macrophages mainly through Toll-like receptor 2 (TLR2)-mediated signalling and to certain extent through TLR4-mediated signalling to induce proinflammatory cytokine production. However, the ability of parasite GPIs to activate dendritic cells (DCs) has not been reported. Here, we show that parasite GPIs efficiently activate DCs through TLR2-mediated signalling mechanism and induce the production of TNF-a and IL-12. We also studied the role of scavenger receptor CD36 in P. falciparum GPI- and merozoite-induced cytokine responses by DCs. The results indicate that CD36 modulates the cytokine-inducing activity of the parasite GPIs by collaborating with TLR2 in DCs. Furthermore, our data reveal that CD36 modulates the activity of P. falciparum merozoites, likely by the contribution of phagocytosis-coupled CD36-mediated signalling to the signalling induced by merozoites. Altogether, these results contribute towards understanding of signalling mechanisms in malaria parasite-induced activation of the innate immune system.
机构:
Univ Sci Tech & Technol Bamako, Malaria Res & Training Ctr, Bamako, MaliDuke Univ, Sch Med, Div Infect Dis, Durham, NC 27710 USA
Diakite, Mahamadou
Taylor, Steve M.
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Duke Univ, Sch Med, Div Infect Dis, Durham, NC 27710 USA
Duke Univ, Duke Global Hlth Inst, Durham, NC USADuke Univ, Sch Med, Div Infect Dis, Durham, NC 27710 USA
机构:
Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic, AustraliaWalter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia
Sampaio, Natalia Guimaraes
Eriksson, Emily Marie
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Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic, AustraliaWalter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia
Eriksson, Emily Marie
Schofield, Louis
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Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia
James Cook Univ, Australian Inst Trop Hlth & Med, Townsville, Qld, AustraliaWalter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia