Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds

被引:46
|
作者
Sung, Ha Yeon [1 ]
Jeong, Yong Taek [2 ]
Lim, Ji Yeon [3 ,4 ]
Kim, Hyeyon [2 ]
Oh, Soo Min [2 ]
Hwang, Sun Wook [3 ,4 ]
Kwon, Jae Young [1 ]
Moon, Seok Jun [2 ]
机构
[1] Sungkyunkwan Univ, Dept Biol Sci, Suwon 16419, Gyeonggi Do, South Korea
[2] Yonsei Univ, Dept Oral Biol, PLUS Project BK21, Coll Dent, Yonsei Ro 50-1, Seoul 03722, South Korea
[3] Korea Univ, Dept Biomed Sci, Coll Med, Seoul 02841, South Korea
[4] Korea Univ, Dept Physiol, Coll Med, Seoul 02841, South Korea
来源
NATURE COMMUNICATIONS | 2017年 / 8卷
基金
新加坡国家研究基金会;
关键词
CAFFEINE RESPONSE; CELLULAR BASIS; BITTER TASTE; AVOIDANCE;
D O I
10.1038/s41467-017-01639-5
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Animals must detect aversive compounds to survive. Bitter taste neurons express heterogeneous combinations of bitter receptors that diversify their response profiles, but this remains poorly understood. Here we describe groups of taste neurons in Drosophila that detect the same bitter compounds using unique combinations of gustatory receptors (GRs). These distinct complexes also confer responsiveness to non-overlapping sets of additional compounds. While either GR32a/GR59c/GR66a or GR22e/GR32a/GR66a heteromultimers are sufficient for lobeline, berberine, and denatonium detection, only GR22e/GR32a/GR66a responds to strychnine. Thus, despite minimal sequence-similarity, Gr22e and Gr59c show considerable but incomplete functional overlap. Since the gain- or loss-of-function of Gr22e or Gr59c alters bitter taste response profiles, we conclude a taste neuron's specific combination of Grs determines its response profile. We suspect the heterogeneity of Gr expression in Drosophila taste neurons diversifies bitter compound detection, improving animal fitness under changing environmental conditions that present a variety of aversive compounds.
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页数:10
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