mTOR: An attractive therapeutic target for osteosarcoma?

被引：22

作者：

Liu Ding ^{[1
]}

Liu Congwei ^{[1
]}

Qing Bei ^{[2
]}

Yang Tao ^{[3
]}

Wang Ruiguo ^{[4
]}

Yu Heze ^{[4
]}

Dou Bo ^{[4
]}

Li Zhihong ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Orthopaed, Changsha, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Thorac Surg, Changsha, Hunan, Peoples R China

[3] Cent South Univ, Xiangya Hosp 2, Dept Otolaryngol Head & Neck Surg, Changsha, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Sch Med, Clin Med Eight Year Program, Changsha, Hunan, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 31期

基金：

中国国家自然科学基金;

关键词：

osteosarcoma; mTOR; target; autophagy; apoptosis; MAMMALIAN TARGET; INHIBITS AUTOPHAGY; ANTITUMOR-ACTIVITY; RAPAMYCIN PATHWAY; INDUCED APOPTOSIS; NUCLEOLAR STRESS; UP-REGULATION; CELL-DEATH; PHASE-II; CANCER;

D O I：

10.18632/oncotarget.9305

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteosarcoma (OS) is a common primary malignant bone tumor with high morbidity and mortality in children and young adults. How to improve poor prognosis of OS due to resistance to chemotherapy remains a challenge. Recently, growing findings show activation of mammalian target of rapamycin (mTOR), is associated with OS cell growth, proliferation, metastasis. Targeting mTOR may be a promising therapeutic approach for treating OS. This review summarizes the roles of mTOR pathway in OS and present research status of mTOR inhibitors in the context of OS. In addition, we have attempted to discuss how to design a better treatment project for OS by combining mTOR inhibitor with other drugs.

引用

页码：50805 / 50813

页数：9

共 50 条

[31] mTOR: on target for novel therapeutic strategies in the nervous system
Maiese, Kenneth
Chong, Zhao Zhong
Shang, Yan Chen
Wang, Shaohui
TRENDS IN MOLECULAR MEDICINE, 2013, 19 (01) : 51 - 60
[32] The mTOR signaling pathway as potential therapeutic target in meningiomas
Mawrin, C.
Andrae, N.
Kirches, E.
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2009, 285 : S97 - S97
[33] mTOR as a therapeutic target for radiation sensitization of glioma vasculature
Lu, B
NEURO-ONCOLOGY, 2005, 7 (03) : 381 - 382
[34] mTOR: A Novel Therapeutic Target for Diseases of Multiple Systems
Chong, Zhao Zhong
CURRENT DRUG TARGETS, 2015, 16 (10) : 1107 - 1132
[35] Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis
Fen Zhang
Ting Cheng
Sheng-Xiao Zhang
Arthritis Research & Therapy, 25
[36] Mammalian Target of Rapamycin (mTOR) as a Potential Therapeutic Target in Pathological Ocular Angiogenesis
Nakahara, Tsutomu
Morita, Akane
Yagasaki, Rina
Mori, Asami
Sakamoto, Kenji
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2017, 40 (12) : 2045 - 2049
[37] Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis
Zhang, Fen
Cheng, Ting
Zhang, Sheng-Xiao
ARTHRITIS RESEARCH & THERAPY, 2023, 25 (01)
[38] Inhibition of CK2: An Attractive Therapeutic Target for Cancer Treatment
Abdel-Magid, Ahmed F.
ACS MEDICINAL CHEMISTRY LETTERS, 2013, 4 (12): : 1131 - 1132
[39] The GABA shunt: An attractive and potential therapeutic target in the treatment of epileptic disorders
Yogeeswari, P
Sriram, D
Vaigundaragavendran, J
CURRENT DRUG METABOLISM, 2005, 6 (02) : 127 - 139
[40] Is nuclear factor κB an attractive therapeutic target for treating cardiac hypertrophy?
Purcell, NH
Molkentin, JD
CIRCULATION, 2003, 108 (06) : 638 - 640

← 1 2 3 4 5 →