Serum α- and γ-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus

被引：20
|
作者：
Uusitalo, L. [1 ,2 ]
Nevalainen, J. [1 ,2 ]
Niinisto, S. [3 ]
Alfthan, G. [4 ]
Sundvall, J. [4 ]
Korhonen, T. [1 ]
Kenward, M. G. [5 ]
Oja, H. [2 ]
Veijola, R. [6 ]
Simell, O. [7 ,8 ,9 ,10 ]
Ilonen, J. [11 ,12 ]
Knip, M. [8 ,9 ,10 ,13 ,14 ]
Virtanen, S. M. [1 ,2 ,15 ]
机构：
[1] Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis Prevent, SF-00300 Helsinki, Finland
[2] Univ Tampere, Tampere Sch Publ Hlth, FIN-33101 Tampere, Finland
[3] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
[4] Natl Publ Hlth Inst, Dept Hlth & Funct Capac, SF-00300 Helsinki, Finland
[5] London Sch Hyg & Trop Med, Med Stat Unit, Dept Epidemiol & Populat Hlth, London WC1, England
[6] Univ Oulu, Dept Pediat, SF-90100 Oulu, Finland
[7] Univ Turku, Dept Pediat, Turku, Finland
[8] Juvenile Diabet Res Fdn Ctr Prevent Type 1 Diabet, Turku, Finland
[9] Juvenile Diabet Res Fdn Ctr Prevent Type 1 Diabet, Oulu, Finland
[10] Juvenile Diabet Res Fdn Ctr Prevent Type 1 Diabet, Tampere, Finland
[11] Univ Kuopio, Dept Clin Microbiol, FIN-70211 Kuopio, Finland
[12] Univ Turku, Immunogenet Lab, Turku, Finland
[13] Tampere Univ Hosp, Dept Pediat, Tampere, Finland
[14] Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland
[15] Tampere Univ Hosp, Res Unit, Tampere, Finland
来源：
DIABETOLOGIA | 2008年 / 51卷 / 05期
基金：
芬兰科学院;
关键词：
aetiology; beta cell autoimmunity; children; cholesterol; alpha-tocopherol; gamma-tocopherol; type; 1; diabetes; vitamin E;
D O I：
10.1007/s00125-008-0959-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims/hypothesis The aim of our study was to assess the associations of serum alpha- and gamma-tocopherol concentrations with the risk of advanced beta cell autoimmunity in children with HLA-conferred genetic susceptibility to type 1 diabetes mellitus. Methods A case-control study with 108 cases with advanced beta cell autoimmunity and 216 matched control participants nested within the birth cohort of the Type 1 Diabetes Prediction and Prevention Project. A serum sample for vitamin E analyses was collected from all the children in the cohort at the age of 1 year and thereafter at 12 month intervals. For each case-control group, all the repeated serum samples up to the age of seroconversion to autoantibody positivity in the case were analysed. A conditional logistic regression model was used to determine potential associations between seroconversion and serum tocopherol concentrations. Results Serum alpha- or gamma-tocopherol concentrations were not significantly associated with the risk of advanced beta cell autoimmunity. The odds ratio (95% CI) for mu mol/l increase in serum concentration of the first-year sample was 0.97 (0.92-1.03) for alpha-tocopherol and 1.10 (0.70-1.74) for gamma-tocopherol. However, there was an interaction between high values of gamma-tocopherol at the age of 1 year and the time of seroconversion (p=0.024). Conclusions/Interpretation It seems unlikely that high concentrations of alpha- or gamma-tocopherol protect against advanced beta cell autoimmunity in young children.
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页码：773 / 780
页数：8
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