PurposeSelf-reported health-related quality of life (HRQoL) represents one central indicator for the need of prevention or intervention with gaining importance for public health monitoring. As part of this framework, the present study aims to identify potentially supportive factors of HRQoL and to determine age-related differences.MethodsIn a sample of young to older adults (18-79years; M=52.71, SD=16.06) from the German Health Interview and Examination Survey for Adults (DEGS1 subsample, n=3667, 52% female), we investigated interrelations between individual (e.g., chronic condition), social (e.g., social support), and lifestyle factors (e.g., healthy eating) and executive functioning with thephysical composite scale (PCS) and themental composite scale (MCS) ofHRQoL with the help of path analyses. Secondly, we performed multiple regression analyses to determine age interactions.ResultsResults suggest direct and indirect paths on PCS, respectively, MCS from various lifestyle factors and executive functioning in addition to individual and social factors with a good model fit (PCS: CD=.63, SRMR=.001; MCS: CD=.64, SRMR=.003). Furthermore, results suggest physical activity and healthy eating to become particularly relevant with advancing age (age group x physical activity on PCS, =.09, p<.05; age groupxhealthy eating on MCS, >.50, p<.01).ConclusionsSeveral lifestyle factors and executive functioning offer the potential to promote HRQoL in the everyday life of individuals at various ages, independent of individual or social determinants. Public health action might want to foster behavioral multicomponent approaches supporting healthy aging.