Michael addition at neutral pH: a facile synthesis of 1,3-dinitroalkanes

被引：7
|
作者：
Bora, Porag [1 ]
Bora, Pranjal P. [1 ]
Wahlang, Barisha [1 ]
Bez, Ghanashyam [1 ]
机构：
[1] North Eastern Hill Univ, Dept Chem, Shillong 793022, Meghalayn, India
来源：
CANADIAN JOURNAL OF CHEMISTRY | 2017年 / 95卷 / 12期
关键词：
1,3-dinitroalkanes; Michael addition; phosphate buffer; base free; diastereoselective; ONE-POT SYNTHESIS; ECONOMIC PASE SYNTHESIS; ANIONIC DOMINO PROCESS; NITROALKANES; ATOM; DERIVATIVES;
D O I：
10.1139/cjc-2017-0257
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Base-catalyzed Michael addition of nitroalkane to conjugated nitroalkene suffers serious practical difficulties due to the formation of oligomeric byproduct. Given its importance for synthesis of pharmacologically relevant organic compounds, a scalable synthesis of 1,3-dinitroalkane is developed by addition of nitroalkane to nitroalkene in aqueous phosphate buffer at pH 7.0 with no added traditional base catalyst.
引用
收藏
页码：1261 / 1266
页数：6
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