Michael addition at neutral pH: a facile synthesis of 1,3-dinitroalkanes

被引：7

作者：

Bora, Porag ^{[1
]}

Bora, Pranjal P. ^{[1
]}

Wahlang, Barisha ^{[1
]}

Bez, Ghanashyam ^{[1
]}

机构：

[1] North Eastern Hill Univ, Dept Chem, Shillong 793022, Meghalayn, India

来源：

CANADIAN JOURNAL OF CHEMISTRY | 2017年 / 95卷 / 12期

关键词：

1,3-dinitroalkanes; Michael addition; phosphate buffer; base free; diastereoselective; ONE-POT SYNTHESIS; ECONOMIC PASE SYNTHESIS; ANIONIC DOMINO PROCESS; NITROALKANES; ATOM; DERIVATIVES;

D O I：

10.1139/cjc-2017-0257

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Base-catalyzed Michael addition of nitroalkane to conjugated nitroalkene suffers serious practical difficulties due to the formation of oligomeric byproduct. Given its importance for synthesis of pharmacologically relevant organic compounds, a scalable synthesis of 1,3-dinitroalkane is developed by addition of nitroalkane to nitroalkene in aqueous phosphate buffer at pH 7.0 with no added traditional base catalyst.

引用

页码：1261 / 1266

页数：6

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