Algorithm-Enabled Low-Dose Micro-CT Imaging

被引:121
|
作者
Han, Xiao [1 ]
Bian, Junguo [1 ]
Eaker, Diane R. [3 ]
Kline, Timothy L. [3 ]
Sidky, Emil Y. [1 ]
Ritman, Erik L. [3 ]
Pan, Xiaochuan [1 ,2 ]
机构
[1] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA
[3] Mayo Clin, Coll Med, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA
基金
美国国家卫生研究院;
关键词
Compressed sensing; image reconstruction; iterative algorithms; low-dose computed tomography; RAY COMPUTED-TOMOGRAPHY; MICROCOMPUTED TOMOGRAPHY; RECONSTRUCTION; BACKPROJECTION; VASCULATURE; PERFORMANCE; PRINCIPLES;
D O I
10.1109/TMI.2010.2089695
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Micro-computed tomography (micro-CT) is an important tool in biomedical research and preclinical applications that can provide visual inspection of and quantitative information about imaged small animals and biological samples such as vasculature specimens. Currently, micro-CT imaging uses projection data acquired at a large number (300-1000) of views, which can limit system throughput and potentially degrade image quality due to radiation-induced deformation or damage to the small animal or specimen. In this work, we have investigated low-dose micro-CT and its application to specimen imaging from substantially reduced projection data by using a recently developed algorithm, referred to as the adaptive-steepest-descent-projection-onto-convex-sets (ASD-POCS) algorithm, which reconstructs an image through minimizing the image total-variation and enforcing data constraints. To validate and evaluate the performance of the ASD-POCS algorithm, we carried out quantitative evaluation studies in a number of tasks of practical interest in imaging of specimens of real animal organs. The results show that the ASD-POCS algorithm can yield images with quality comparable to that obtained with existing algorithms, while using one-sixth to one quarter of the 361-view data currently used in typical micro-CT specimen imaging.
引用
收藏
页码:606 / 620
页数:15
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