A non-peptide ligand for the somatostatin receptor having a benzodiazepinone structure

被引：40
|
作者：
Papageorgiou, C
Borer, X
机构：
[1] Sandoz Pharma Ltd., Preclinical Research
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 03期
关键词：
D O I：
10.1016/0960-894X(96)00003-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The 1,3,4-trisubstituted-1,4-benzodiazepin-2-one 2 is a non-peptide mimic of somatostatin 1. It displaces the radioligand [I-125-Tyr(3)]-octreotide with an IC50 Of 7 mu M.
引用
收藏
页码：267 / 272
页数：6
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