MOLECULAR PROBES Getting lucky in the lysosome

被引：2
|
作者：
Goddard-Borger, Ethan D. [1 ,2 ]
Wennekes, Tom [1 ,2 ]
Withers, Stephen G. [1 ,2 ]
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC, Canada
[2] Univ British Columbia, Ctr High Throughput Biol, Vancouver, BC V5Z 1M9, Canada
来源：
NATURE CHEMICAL BIOLOGY | 2010年 / 6卷 / 12期
关键词：
ISOFAGOMINE INCREASES; BETA-GLUCOSIDASE; GAUCHER-DISEASE; GLUCOCEREBROSIDASE; FIBROBLASTS; THERAPY;
D O I：
10.1038/nchembio.470
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Conjugation of a known, mechanism-based glycosidase inhibitor to sensitive fluorophores yielded unexpectedly potent and selective probes for quantifying active lysosomal glucocerebrosidase. These conjugates could prove to be invaluable tools for diagnosing and studying Gaucher disease.
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页码：881 / 883
页数：4
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