Copy-number polymorphisms:: mining the tip of an iceberg

被引：32
|
作者：
Buckley, PG [1 ]
Mantripragada, KK [1 ]
Piotrowski, A [1 ]
de Ståhl, TD [1 ]
Dumanski, JP [1 ]
机构：
[1] Univ Uppsala, Rudbeck Lab, Dept Genet & Pathol, S-75185 Uppsala, Sweden
来源：
TRENDS IN GENETICS | 2005年 / 21卷 / 06期
关键词：
D O I：
10.1016/j.tig.2005.04.007
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Copy-number polymorphisms (CNPs) represent a greatly underestimated aspect of human genetic variation. Recently, two landmark studies reported genome-wide analyses of CNPs in normal individuals and represent the beginning of an understanding of this type of large-scale variation. Future array-CGH-based CNP analyses should include standard criteria on a common microarray platform. It is only when parallel analyses of CNPs and SNPs are performed in an integrated format that we will obtain a global picture of our genetic diversity.
引用
收藏
页码：315 / 317
页数：3
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