α-glucosidase inhibitory pentacyclic triterpenoids from the leaves of Cleistocalyx conspersipunctatus

被引：4
|
作者：
Du, Haifang [1 ,3 ]
Li, Hanxiang [1 ,2 ]
Wu, Ping [1 ,2 ,3 ]
Wang, Chen [1 ,3 ]
Xue, Jinghua [1 ,2 ]
Wei, Xiaoyi [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Xingke Rd 723, Guangzhou 510650, Guangdong, Peoples R China
[2] Chinese Acad Sci, Guangdong Prov Key Lab Appl Bot, South China Bot Garden, Xingke Rd 723, Guangzhou 510650, Guangdong, Peoples R China
[3] Univ Chinese Acad Sci, Yuquanlu19A, Beijing 100049, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2021年 / 41卷
关键词：
Cleistocalyx conspersipunctatus; Pentacyclic triterpenoid; alpha-Glucosidase inhibition; CONSTITUENTS;
D O I：
10.1016/j.phytol.2020.11.005
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new pentacyclic triterpenoids, 6a-hydroxyursolic acid (1), 6 alpha-hydroxycorosolic acid (2), 6-oxo-maslinic acid (3), 6-oxo-delta-maslinic acid (4), and 6-oxo-alphitolic acid (5), along with 15 known analogues were isolated from the leaves of Cleistocalyx conspersipunctatus. Their structures were elucidated by spectroscopic analysis. Compound 1 displayed better alpha-glucosidase inhibitory activity (IC50: 2.6 mu M) than the known inhibitor corosolic acid (IC50: 15.5 mu M). Structure-activity relationships in the activity were discussed for this group of isolates.
引用
收藏
页码：109 / 113
页数：5
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