In Vitro Efficacy of Moxidectin versus Ivermectin against Sarcoptes scabiei

被引：3
|
作者：
Mounsey, Kate E. [1 ]
Walton, Shelley F. [1 ]
Innes, Ashlee [1 ]
Cash-Deans, Skye [1 ]
McCarthy, James S. [2 ,3 ]
机构：
[1] Univ Sunshine Coast, Fac Sci Hlth Educ & Engn, Sch Hlth & Sport Sci, Inflammat & Healing Cluster, Sippy Downs, Qld, Australia
[2] QIMR Berghofer Med Res Inst, Herston, Qld, Australia
[3] Univ Queensland, Herston, Qld, Australia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 08期
关键词：
ivermectin; moxidectin; Sarcoptes scabiei; scabies; treatment; MACROCYCLIC LACTONES; BENZYL BENZOATE; RESISTANCE; ASSAY; MOTILITY; SAFETY; CATTLE; MANGE;
D O I：
10.1128/AAC.00381-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Moxidectin is under consideration for development as a treatment for human scabies. As some arthropods show decreased sensitivity to moxidectin relative to ivermectin, it was important to assess this for Sarcoptes scabiei. In vitro assays showed that the concentration of moxidectin required to kill 50% of mites was lower than that of ivermectin (0.5 mu M versus 1.8 mu M at 24 h; P < 0.0001). This finding provides further support for moxidectin as a candidate for the treatment of human scabies.
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页数：5
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