Effect of ca2+ to salicylic acid release in pectin based controlled drug delivery system

Wastes from orange peel are potentially be utilized to produce pectin, which are currently an import commodity. Pectin can be used in making edible film. Edible films are potentially used as a drug delivery system membrane after a tooth extraction. Drug which is used in the drug delivery system is salicylic acid. It is an antiseptic. In order to control the drug release rate, crosslinking process is added in the manufacturing of membrane with CaCl2 center dot 2H(2)O as crosslinker. Pectin was diluted in water and mixed with a plasticizer and CaCl2 center dot 2H(2)O solution at 66 degrees C to make edible film. Then the mixture was dried in an oven at 50 degrees C. After edible film was formed, it was coated using plasticizer and CaCl(2 center dot)2H(2)O solution with various concentration 0, 0.015, 0.03 and 0.05g/mL. This study showed that the more concentration of crosslinker added, the slower release of salicylic acid would be. This was indicated by the value of diffusivites were getting smaller respectively. The addition of crosslinker also caused smaller gels swelling value, which made the membrane is mechanically stronger.