Ethanol and hormesis

被引：41

作者：

Calabrese, EJ ^{[1
]}

Baldwin, LA ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Environm Hlth Sci, Amherst, MA 01003 USA

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2003年 / 33卷 / 3-4期

关键词：

ethanol; hormesis; biphasic; J-shaped; U-shaped; animal models; risk assessment; nonlinear; dual effects; switching mechanisms; bi-directional responses; stimulation; inhibition;

D O I：

10.1080/713611043

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This article provides a detailed assessment of the toxicological and pharmacological literature concerning alcohol-induced biphasic dose-response relationships. The assessment reveals that alcohol-induced hormetic-like dose-response relationships are commonly observed, highly generalizeable according to model and endpoint and quantitative feature of the dose response. These findings have important implications affecting study design, animal model, and endpoint selection as well as clinical applications.

引用

页码：407 / 424

页数：18

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