Physicochemical characterization of protein-loaded pectin-chitosan nanoparticles prepared by polyelectrolyte complexation

被引：10

作者：

Grabnar, P. Ahlin ^{[1
]}

Kristl, J. ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Pharm, Ljubljana 1000, Slovenia

来源：

PHARMAZIE | 2010年 / 65卷 / 11期

关键词：

D O I：

10.1691/ph.2010.0197

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recent advances in nanotechnology applied to proteins are directed towards safer and simpler methods of preparation, using naturally occurring polymers such as alginate, pectin and chitosan. In this study, pectin-chitosan nanoparticles (NPs) were designed by the mild process of polyelectrolyte complexation, which occurs at room temperature without using sonication or organic solvents. NPs with a mean diameter between 300 and 400 nm and 45 to 86% protein association efficiency were obtained by varying the pectin:chitosan mass ratio and initial protein concentration. A prolonged release profile without burst effect of investigated ovalbumin from pectin-chitosan NPs was determined.

引用

页码：851 / 852

页数：2

共 50 条

[41] Modulating physicochemical, antimicrobial and release properties of chitosan/zein bilayer films with curcumin/nisin-loaded pectin nanoparticles
Zhang, Liming
Chen, Danying
Yu, Dawei
Regenstein, Joe M.
Jiang, Qixing
Dong, Junli
Chen, Wanwen
Xia, Wenshui
Food Hydrocolloids, 2022, 133
[42] Modulating physicochemical, antimicrobial and release properties of chitosan/zein bilayer films with curcumin/nisin-loaded pectin nanoparticles
Zhang, Liming
Chen, Danying
Yu, Dawei
Regenstein, Joe M.
Jiang, Qixing
Dong, Junli
Chen, Wanwen
Xia, Wenshui
FOOD HYDROCOLLOIDS, 2022, 133
[43] Preparation, characterization and antibacterial activities of chitosan, N-trimethyl chitosan (TMC) and N-diethylmethyl chitosan (DEMC) nanoparticles loaded with insulin using both the ionotropic gelation and polyelectrolyte complexation methods
Sadeghi, A. M. M.
Dorkoosh, F. A.
Avadi, M. R.
Saadat, P.
Rafiee-Tehrani, M.
Junginger, H. E.
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 355 (1-2) : 299 - 306
[44] Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers
Mukherjee, Biswajit
Santra, Kousik
Pattnaik, Gurudutta
Ghosh, Soma
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2008, 3 (04): : 487 - 496
[45] Characterization of tea catechins-loaded nanoparticles prepared from chitosan and an edible polypeptide
Tang, Deh-Wei
Yu, Shu-Huei
Ho, Yi-Cheng
Huang, Bing-Quan
Tsai, Guo-Jane
Hsieh, Hao-Ying
Sung, Hsing-Wen
Mi, Fwu-Long
FOOD HYDROCOLLOIDS, 2013, 30 (01) : 33 - 41
[46] Suppression of palmitic acid-induced hepatic oxidative injury by neohesperidin-loaded pectin-chitosan decorated nanoliposomes
Karim, Naymul
Shishir, Mohammad Rezaul Islam
Rashwan, Ahmed K.
Ke, Huihui
Chen, Wei
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 183 : 908 - 917
[47] Chitosan-pectin hybrid nanoparticles prepared by coating and blending techniques
Rampino, A.
Borgogna, M.
Bellich, B.
Blasi, P.
Virgilio, F.
Cesaro, A.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 84 : 37 - 45
[48] Characterization of novel lactoferrin loaded capsules prepared with polyelectrolyte complexes
Wu, Qing-Xi
Zhang, Qi-Lei
Lin, Dong-Qiang
Yao, Shan-Jing
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 455 (1-2) : 124 - 131
[49] Characterization of protein-loaded poly(ε-caprolactone) microparticles based on a factorial design
Lin, WJ
Huang, LI
Chang, RRL
JOURNAL OF MICROENCAPSULATION, 2001, 18 (02) : 183 - 189
[50] Annealing as a tool for the optimization of lyophilization and ensuring of the stability of protein-loaded PLGA nanoparticles
Fonte, Pedro
Lino, Paulo Roque
Seabra, Vitor
Almeida, Antonio J.
Reis, Salette
Sarmento, Bruno
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 503 (1-2) : 163 - 173

← 1 2 3 4 5 →