TBHP/TBAI-Mediated simple and efficient synthesis of 3,5-disubstituted and 1,3,5-trisubstituted 1H-1,2,4-triazoles via oxidative decarbonylation of aromatic aldehydes and testing for antibacterial activities

The author has developed a simple, efficient and eco-friendly convenient general method for synthesis of 3,5-disubstituted-1,2,4-triazoles and 1,3,5-trisubstituted-1,2,4-triazoles from 3-monosubstituted-1,2,4-triazoles and 1,3-disubstituted-1,2,4-triazoles respectively using tetrabutylammonium iodide (TBAI) as catalyst and TBHP as oxidant under mid reaction conditions. This method provides structurally diverse 3,5-disubstituted 1,2,4-triazoes and 1,3,5-trisubstituted-1,2,4-triazoles in good to excellent yields. 3,5-Disubstituted 1,2,4-triazoes and 1,3,5-trisubstituted-1,2,4-triazoles derivatives are biologically and pharmaceutically active molecules, and therefore, this protocol could be of wide applications in medicinal chemistry and organic chemistry. (C) 2020 Elsevier Ltd. All rights reserved.