The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS

被引：199

作者：

Kadowaki, Takashi ^{[1
,2
]}

Yamauchi, Toshimasa ^{[1
,3
]}

Kubota, Naoto ^{[1
,2
,3
]}

机构：

[1] Univ Tokyo, Dept Metab Dis, Grad Sch Med, Tokyo, Japan

[2] Natl Inst Hlth & Nutr, Div Appl Nutr, Tokyo 162, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Integrated Mol Sci Metab Dis, Tokyo, Japan

来源：

FEBS LETTERS | 2008年 / 582卷 / 01期

关键词：

adiponectin; adipoectin receptor; metabolic syndrome; AMP-activated protein kinase (AMPK); energy homeostasis; starvation gene;

D O I：

10.1016/j.febslet.2007.11.070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adiponectin is an abundantly expressed adipokine in adipose tissue and has direct insulin sensitizing activity. A decrease in the circulating levels of adiponectin by interactions between genetic factors and environmental factors causing obesity has been shown to contribute to the development of insulin resistance, type 2 diabetes, metabolic syndrome and atherosclerosis. In addition to its insulin sensitizing actions, adiponectin has central actions in the regulation of energy homeostasis. Adiponectin enhances AMP-activated protein kinase activity in the arcuate hypothalamus via its receptor AdipoR1 to stimulate food intake and decreases energy expenditure. We propose a hypothesis on the physiological role of adiponectin: a starvation gene in the course of evolution by promoting fat storage on facing the loss of adiposity. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：74 / 80

页数：7

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