Differential Effects of Lateral and Medial Entorhinal Cortex Lesions on Trace, Delay and Contextual Fear Memories

被引:4
|
作者
East, Brett S.
Brady, Lauren R.
Quinn, Jennifer J. [1 ]
机构
[1] Miami Univ, Dept Psychol, 90 N Patterson Ave, Oxford, OH 45056 USA
基金
美国国家卫生研究院;
关键词
expression; consolidation; learning; memory; rat; DORSAL HIPPOCAMPUS; PERIRHINAL CORTEX; POTENTIATED STARTLE; NEUROTOXIC LESIONS; CORTICAL AFFERENTS; AMYGDALA; ASSOCIATION; ACQUISITION; DISSOCIATION; INVOLVEMENT;
D O I
10.3390/brainsci12010034
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The entorhinal cortex (EC), with connections to the hippocampus, amygdala, and neocortex, is a critical, yet still underexplored, contributor to fear memory. Previous research suggests possible heterogeneity of function among its lateral (LEC) and medial (MEC) subregions. However, it is not well established what unique roles these subregions serve as the literature has shown mixed results depending on target of manipulation and type of conditioning used. Few studies have manipulated both the LEC and MEC within the same experiment. The present experiment systematically manipulated LEC and MEC function to examine their potential roles in fear memory expression. Long-Evans rats were trained using either trace or delay fear conditioning. The following day, rats received an N-methyl-D-aspartate (NMDA)-induced lesion to the LEC or MEC or received a sham surgery. Following recovery, rats were given an 8-min context test in the original context. The next day, rats were tested for tone freezing in a novel context with three discrete tone presentations. Further, rats were tested for hyperactivity in an open field under both dark and bright light gradient conditions. Results: Following either LEC or MEC lesion, freezing to context was significantly reduced in both trace and delay conditioned rats. LEC-lesioned rats consistently showed significantly less freezing following tone-offset (trace interval, or equivalent, and intertrial interval) in both trace and delay fear conditioned rats. Conclusions: These data suggest that the LEC may play a role in the expression of a conjunctive representation between the tone and context that mediates the maintenance of post-tone freezing.
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页数:14
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