High Prevalence of Vitamin D Deficiency in Pregnant Korean Women: The First Trimester and the Winter Season as Risk Factors for Vitamin D Deficiency

被引:62
|
作者
Choi, Rihwa [1 ]
Kim, Seonwoo [2 ]
Yoo, Heejin [3 ]
Cho, Yoon Young [4 ]
Kim, Sun Wook [4 ]
Chung, Jae Hoon [4 ]
Oh, Soo-young [5 ]
Lee, Soo-Youn [1 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul 135710, South Korea
[2] Samsung Biomed Res Inst, Biostat Team, Seoul 135710, South Korea
[3] Samsung Med Ctr, Biostat & Clin Epidemiol Ctr, Seoul 135710, South Korea
[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, Seoul 135710, South Korea
[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Obstet & Gynecol, Seoul 135710, South Korea
关键词
SERUM 25-HYDROXYVITAMIN D-3; HYPOVITAMINOSIS D; D INSUFFICIENCY; OUTCOMES; ASSOCIATION;
D O I
10.3390/nu7053427
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
We investigated the vitamin D status of Korean women during pregnancy and assessed the effects of vitamin D deficiency on two pregnancy outcomes; preterm births and the births of small for gestational age. We measured the serum 25-hydroxyvitamin D levels in 220 pregnant Korean women who were recruited prospectively and compared these levels with those of 500 healthy non-pregnant women. We analyzed vitamin D status according to patient demographics, season, and obstetrical characteristics; moreover, we also assessed pregnancy outcomes. The overall prevalence of vitamin D deficiency(<20 ng/mL) in pregnant women and healthy non-pregnant women was 77.3% and 79.2%; respectively; and the prevalence of severe vitamin D deficiency (<10 ng/mL) was 28.6% and 7.2%; respectively (p < 0.05). Vitamin D deficiency was more prevalent in the winter (100%) than in the summer (45.5%) in pregnant Korean women. A higher risk of vitamin D deficiency was observed in the first trimester than in the third trimester (adjusted OR 4.3; p < 0.05). No significant association was observed between vitamin D deficiency and any of the pregnancy outcomes examined. Further research focusing on the long-term consequences of vitamin D deficiency during pregnancy in Korean women is warranted.
引用
收藏
页码:3427 / 3448
页数:22
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