Enantioselective synthesis of (S)-α-arylpropionic acids via Pd-catalyzed kinetic resolution of benzylic alcohols

被引：0
|
作者：
Thakur, VV [1 ]
Sudalai, A [1 ]
机构：
[1] Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2005年 / 44卷 / 03期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient synthetic route for the synthesis of three (S)-alpha-propionic acids, (S)-naproxen (90% ee), (S)-ibuprofen (82% ee) and (S)-phenylpropioilic acid (92% ee) is described. Pd-catalyzed oxidative kinetic resolution of the corresponding benzylic alcohols is used as a key step to introduce stereogenicity into the molecule.
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页码：557 / 562
页数：6
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