Reduced prepulse inhibition as an early vulnerability marker of the psychosis prodrome in adolescence

被引:43
|
作者
Ziermans, Tim B. [1 ,2 ]
Schothorst, Patricia F. [2 ]
Sprong, Mirjam [2 ]
Magnee, Maurice J. C. M. [2 ]
van Engeland, Herman [2 ]
Kemner, Chantal [2 ,3 ]
机构
[1] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden
[2] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Child & Adolescent Psychiat, Utrecht, Netherlands
[3] Univ Utrecht, Fac Social Sci, Dept Dev Psychol, NL-3508 TC Utrecht, Netherlands
关键词
Ultra-high risk for psychosis; p50; Prepulse inhibition; Smooth pursuit; ULTRA-HIGH-RISK; 2-YEAR FOLLOW-UP; NEUROPHYSIOLOGICAL ENDOPHENOTYPES; P50; SUPPRESSION; P300; AMPLITUDE; SCHIZOPHRENIA; STARTLE; INDIVIDUALS; EPISODE; ANTIPSYCHOTICS;
D O I
10.1016/j.schres.2011.10.009
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: The onset of psychosis is thought to be preceded by neurodevelopmental changes in the brain. However, the timing and nature of these changes have not been established. The aim of the present study was to determine whether three "classic" neurophysiological markers of schizophrenia are also characteristic of young adolescents (12-18 years) at ultra-high risk for psychosis (UHR). Methods: 63 young UHR individuals and 68 typically developing, age-, sex- and IQ-matched controls were recruited for neurophysiological assessment. Data for P50 suppression, prepulse inhibition (PPI) and smooth pursuit eye movements (SPEM) were gathered and compared. Results: UHR individuals showed reduced PPI compared to controls, which became more pronounced when controls were directly compared to medication-naive UHR individuals (N=39). There were no group differences in P50 or SPEM measures. Conclusions: These results suggest that PPI is a relatively early vulnerability marker, while changes in other neurophysiological measures may only be detected or affected later during the illness course. Antipsychotic and antidepressant medication may aid in elevating PPI levels and potentially have a neuroprotective effect. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:10 / 15
页数:6
相关论文
共 50 条
  • [31] Magnetic resonance imaging correlates of prepulse inhibition in first episode psychosis
    Ettinger, U
    Kumari, V
    Chitnis, XA
    Sumich, AL
    Fannon, DG
    Soni, W
    O'Ceallaigh, S
    Sharma, T
    SCHIZOPHRENIA RESEARCH, 2000, 41 (01) : 146 - 146
  • [32] Prepulse inhibition as a marker of prefrontal function: Studies in healthy individuals
    Bitsios, P.
    EUROPEAN PSYCHIATRY, 2008, 23 : S69 - S70
  • [33] THE STRUCTURE OF THE EXTENDED PSYCHOSIS PHENOTYPE IN EARLY ADOLESCENCE
    Wigman, Johanna T. W.
    Vollebergh, Wilma A. M.
    Raaijmakers, Quinten A. W.
    Iedema, Jurjen
    van Dorsselaer, Saskia
    Ormel, Johan
    Verhulst, Frank C.
    van Os, Jim
    SCHIZOPHRENIA RESEARCH, 2010, 117 (2-3) : 322 - 322
  • [34] Prepulse inhibition of startle is reduced in family members of schizophrenia patients
    Hasenkamp, Wendy
    Kelley, Mary
    Egan, Glenn
    Green, Amanda
    Lewison, Barbara
    Boshoven, William
    Duncan, Erica J.
    NEUROPSYCHOPHARMACOLOGY, 2006, 31 : S124 - S125
  • [35] Creating a National Early Psychosis Clinical Support Program in the United States: The Development of the Prodrome and Early Psychosis Program Network (PEPPNET)
    Adelsheim, Steven
    Harrison, Vicki
    Heinssen, Robert
    Lowe, Jane Isaacs
    Blau, Gary M.
    EARLY INTERVENTION IN PSYCHIATRY, 2016, 10 : 99 - 99
  • [36] Prepulse inhibition is reduced in mice with the testicular feminization mutation.
    Zuloaga, DG
    Morris, JA
    Jordan, CL
    Breedlove, SM
    HORMONES AND BEHAVIOR, 2005, 48 (01) : 135 - 136
  • [37] Prepulse inhibition of startle is reduced in family members of schizophrenia patients
    Hasenkamp, W.
    Kelley, M.
    Egan, G.
    Green, A.
    Lewison, B.
    Boshoven, B.
    Keyes, M.
    Duncan, E.
    SCHIZOPHRENIA BULLETIN, 2007, 33 (02) : 405 - 405
  • [38] Maternal Behavior and Cognitive Vulnerability in Early Adolescence
    Tompson, Martha C.
    Langer, David A.
    Davila, Joanne
    INTERNATIONAL JOURNAL OF COGNITIVE THERAPY, 2012, 5 (03): : 268 - 282
  • [39] Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood
    Darbra, Sonia
    Pallares, Marc
    PSYCHONEUROENDOCRINOLOGY, 2010, 35 (04) : 525 - 535
  • [40] Neurological soft signs and prepulse inhibition of the startle reflex in psychosis: A pilot study
    Ira, Elisa
    Bonetto, Chiara
    Zanoni, Martina
    Bottacini, Alessandro
    Mazzoncini, Rodolfo
    Martini, Lisa
    Garozzo, Angela
    Lasalvia, Antonio
    Tansella, Michele
    Ruggeri, Mirella
    Tosato, Sarah
    INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 2015, 19 (04) : 277 - 285