Carbohydrate specificities of the murine DC-SIGN homologue mSIGNR1

被引：12

作者：

Koppel, EA ^{[1
]}

Ludwig, IS ^{[1
]}

Appelmelk, BJ ^{[1
]}

van Kooyk, Y ^{[1
]}

Geijtenbeek, TBH ^{[1
]}

机构：

[1] VU Univ Med Ctr Amsterdam, NL-1081 BT Amsterdam, Netherlands

来源：

IMMUNOBIOLOGY | 2005年 / 210卷 / 2-4期

关键词：

C-type lectins; Lewis antigens; macrophages; pathogen;

D O I：

10.1016/j.imbio.2005.05.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

C-type lectins are important receptors expressed by antigen presenting cells that are involved in cellular communications as well as in pathogen uptake. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we have investigated the carbohydrate specificity of cellular mSIGNR1 and compared it with DC-SIGN and L-SIGN. mSIGNR1 has a similar specificity as human DC-SIGN for high mannose-containing ligands present on both cellular and pathogen ligands. However, the DC-SIGN molecules differ in their recognition of Lewis antigens; mSIGNR1 interacts not only with Le(x/y) and Le(a/b) antigens similar to DC-SIGN, but also with sialylated Le(x), a ligand for selectins. The differential recognition of Lewis antigens suggests differences between mSIGNR1 and DC-SIGN in the recognition of cellular ligands and pathogens that express Lewis epitopes. (C) 2005 Elsevier GmbH. All rights reserved.

引用

页码：195 / 201

页数：7

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