Carbohydrate specificities of the murine DC-SIGN homologue mSIGNR1

被引：12
|
作者：
Koppel, EA [1 ]
Ludwig, IS [1 ]
Appelmelk, BJ [1 ]
van Kooyk, Y [1 ]
Geijtenbeek, TBH [1 ]
机构：
[1] VU Univ Med Ctr Amsterdam, NL-1081 BT Amsterdam, Netherlands
来源：
IMMUNOBIOLOGY | 2005年 / 210卷 / 2-4期
关键词：
C-type lectins; Lewis antigens; macrophages; pathogen;
D O I：
10.1016/j.imbio.2005.05.012
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
C-type lectins are important receptors expressed by antigen presenting cells that are involved in cellular communications as well as in pathogen uptake. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we have investigated the carbohydrate specificity of cellular mSIGNR1 and compared it with DC-SIGN and L-SIGN. mSIGNR1 has a similar specificity as human DC-SIGN for high mannose-containing ligands present on both cellular and pathogen ligands. However, the DC-SIGN molecules differ in their recognition of Lewis antigens; mSIGNR1 interacts not only with Le(x/y) and Le(a/b) antigens similar to DC-SIGN, but also with sialylated Le(x), a ligand for selectins. The differential recognition of Lewis antigens suggests differences between mSIGNR1 and DC-SIGN in the recognition of cellular ligands and pathogens that express Lewis epitopes. (C) 2005 Elsevier GmbH. All rights reserved.
引用
收藏
页码：195 / 201
页数：7
相关论文
共 50 条
  • [1] The murine homologue of DC-SIGN, mSIGNR1, is targeted by pathogens to modulatethe immune response in vivo
    不详
    [J]. IMMUNOBIOLOGY, 2004, 209 (4-6) : 386 - 387
  • [2] Distinct functions of DC-SIGN and its homologues L-SIGN and mSIGNR1 in pathogen recognition and immune regulation
    Quintana-Murci, L
    [J]. M S-MEDECINE SCIENCES, 2006, 22 (01): : 29 - 32
  • [3] Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation
    Koppel, EA
    van Gisbergen, KPJM
    Geijtenbeek, TBH
    van Kooyk, Y
    [J]. CELLULAR MICROBIOLOGY, 2005, 7 (02) : 157 - 165
  • [4] A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis
    Tanne, Antoine
    Ma, Bo
    Boudou, Frederic
    Tailleux, Ludovic
    Botella, Helene
    Badell, Edgar
    Levillain, Florence
    Taylor, Maureen E.
    Drickamer, Kurt
    Nigou, Jerome
    Dobos, Karen M.
    Puzo, Germain
    Vestweber, Dietmar
    Wild, Martin K.
    Marcinko, Marie
    Sobieszczuk, Peter
    Stewart, Lauren
    Lebus, Daniel
    Gicquel, Brigitte
    Neyrolles, Olivier
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (10): : 2205 - 2220
  • [5] A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis
    Tanne, Antoine
    Neyrolles, Olivier
    [J]. VIRULENCE, 2010, 1 (04) : 285 - 290
  • [6] TARGETING DC-SIGN WITH CARBOHYDRATE MULTIVALENT SYSTEMS
    Sanchez-Navarro, Macarena
    Rojo, Javier
    [J]. DRUG NEWS & PERSPECTIVES, 2010, 23 (09) : 557 - 572
  • [7] Murine MAb to a peptide epitope in human DC-sign
    Berry, JD
    [J]. HYBRIDOMA, 2005, 24 (04): : 221 - 222
  • [8] Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo
    Geijtenbeek, TBH
    Groot, PC
    Nolte, MA
    van Vliet, SJ
    Gangaram-Panday, ST
    van Duijnhoven, GCF
    Kraal, G
    van Oosterhout, AJM
    van Kooyk, Y
    [J]. BLOOD, 2002, 100 (08) : 2908 - 2916
  • [9] Glycomimetic and non-carbohydrate inhibitors as probes of the lectin DC-SIGN
    Kiessling, Laura L.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [10] Activation of DC-SIGN Promoter and Common Signaling Pathways Between HIV-1 5′LTR and DC-SIGN
    Jin, Changzhong
    Wu, Lijuan
    Li, Jie
    Cheng, Linfang
    Wang, Juan
    Wu, Nanping
    [J]. LABMEDICINE, 2013, 44 (02): : 129 - 132
12345