Expression of SMURF1 is Increased in Patients With Pulmonary Arterial Hypertension and SiRNA Inhibition of SMURF1 Reduces Pulmonary Artery Smooth Muscle Cell Proliferation

被引：0
|
作者：
Rothman, Alex M. [1 ]
West, Laura [1 ]
Srivastava, Salil [2 ]
Quigley, Catherine [2 ]
Southwood, Mark [3 ]
Lawrie, Allan [1 ]
Francis, Sheila [1 ]
Morrell, Nick [4 ]
Rowlands, David [2 ]
机构：
[1] Univ Sheffield, Inflammat Infect & Cardiovasc Dis, Sheffield, S Yorkshire, England
[2] Novartis Inst Biomed Rsch, Resp Dis, Cambridge, MA USA
[3] Papworth Hosp, Dept Pathol, Cambridge, England
[4] Univ Cambridge, Dept Med, Cambridge, England
来源：
CIRCULATION | 2018年 / 138卷
关键词：
Pulmonary hypertension; Pulmonary vascular biology; Ubiquitin; Smooth muscle;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A14742
引用
收藏
页数：2
相关论文
共 50 条
  • [21] miR-1254 inhibits cell proliferation, migration, and invasion by down-regulating Smurf1 in gastric cancer
    Mingkun Jiang
    Liang Shi
    Chao Yang
    Yugang Ge
    Linling Lin
    Hao Fan
    Yu He
    Diancai Zhang
    Yongchang Miao
    Li Yang
    Cell Death & Disease, 10
  • [22] Therapeutic Potential of Smurf-1 Inhibitors for the Treatment of Pulmonary Arterial Hypertension (PAH)
    Abdel-Magid, Ahmed F.
    ACS MEDICINAL CHEMISTRY LETTERS, 2016, 7 (10): : 878 - 880
  • [23] Insulin-like growth factor-1 contributes to the pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension
    Dewachter, Laurence
    Dewachter, Celine
    Belhaj, Asmae
    Lalande, Sophie
    Rondelet, Benoit
    Remmelink, Myriam
    Vachiery, Jean-Luc
    Naeije, Robert
    EUROPEAN RESPIRATORY JOURNAL, 2014, 44
  • [24] Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension
    Houssaini, Amal
    Abid, Shariq
    Mouraret, Nathalie
    Wan, Feng
    Rideau, Dominique
    Saker, Mirna
    Marcos, Elisabeth
    Tissot, Claire-Marie
    Dubois-Rande, Jean-Luc
    Amsellem, Valerie
    Adnot, Serge
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2013, 48 (05) : 568 - 577
  • [25] Participation of PLK1 and FOXM1 in the hyperplastic proliferation of pulmonary artery smooth muscle cells in pulmonary arterial hypertension
    Wilson, Jamie L.
    Wang, Lizhen
    Zhang, Zeyu
    Hill, Nicholas S.
    Polgar, Peter
    PLOS ONE, 2019, 14 (08):
  • [26] Xav939 Attenuates Pulmonary Arterial Hypertension by Reducing Pulmonary Artery Smooth Muscle Cell Proliferation
    Li, Dan
    Peng, Xin
    Huang, Wei
    CIRCULATION, 2019, 140
  • [27] Prednisolone inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension
    Ogawa, A
    Nakamura, K
    Matsubara, H
    Fujio, H
    Ikeda, T
    Kobayashi, K
    Miyazaki, I
    Asanuma, M
    Miyaji, K
    Miura, D
    Kusano, KF
    Date, H
    Ohe, T
    CIRCULATION, 2005, 112 (12) : 1806 - 1812
  • [28] Carvedilol inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension
    Fujio, H
    Nakamura, K
    Matsubara, H
    Kusano, KF
    Miyaji, K
    Nagase, S
    Ikeda, T
    Ogawa, A
    Ohta-Ogo, K
    Miura, D
    Miura, A
    Miyazaki, M
    Date, H
    Ohe, T
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2006, 47 (02) : 250 - 255
  • [29] Camkii Is Necessary For Increased Proliferation And Migration Of Pulmonary Arterial Smooth Muscle Cells In Pulmonary Hypertension
    Huetsch, J.
    Jiang, H.
    Shimoda, L.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
  • [30] Wnt Independent B-Catenin Activation Is Associated With Increased Pulmonary Artery Smooth Muscle Cell Proliferation In Idiopathic Pulmonary Arterial Hypertension
    Takahashi, J.
    Orcholski, M.
    Liao, X.
    Rojas, V.
    Yuan, K.
    Perez, V. De Jesus
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187
12345