Organocatalytic Asymmetric Fluorination of 4-Substituted Isoxazolinones

被引：30

作者：

Zhang, Huanrui ^{[1
]}

Wang, Baomin ^{[1
]}

Cui, Longchen ^{[1
]}

Bao, Xiaoze ^{[1
]}

Qu, Jingping ^{[1
]}

Song, Yuming ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Sch Pharmaceut Sci & Technol, Dalian 116024, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Isoxazolinone; Organocatalysis; Cinchona alkaloid; Fluorine; Heterocycles; ENANTIOSELECTIVE CONJUGATE ADDITION; MICHAEL ADDITION; CARBONYL-COMPOUNDS; EFFICIENT APPROACH; C-ALKYLATION; 5H-OXAZOL-4-ONES; DERIVATIVES; MALONATE; TRIFLUOROMETHYLATION; NITROALKENES;

D O I：

10.1002/ejoc.201500046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward method for the asymmetric fluorination of 4-substituted isoxazolinones catalyzed by a bis-cinchona alkaloid catalyst was developed. A series of 4-fluoroisoxazolinone derivatives with a fluorine-containing quaternary stereocenter were obtained in good to high yields with good enantioselectivities (up to 91% yield, 85% ee).

引用

页码：2143 / 2147

页数：5

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