Chiral iminophosphorane catalyzed asymmetric sulfenylation of 4-substituted pyrazolones

被引：28
|
作者：
Han, Jianwei [1 ,2 ]
Zhang, Yanxia [1 ,2 ]
Wu, Xin-Yan [1 ]
Wong, Henry N. C. [2 ]
机构：
[1] East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 03期
基金：
中国国家自然科学基金;
关键词：
MICHAEL ADDITION; STEREOCONTROLLED CONSTRUCTION; ENANTIOSELECTIVITY; PYRAZOL-5-ONES; TEMPERATURE; ALKYLATION; QUATERNARY; PYRAZOLIN-5-ONES; PALLADIUM; KETONES;
D O I：
10.1039/c8cc09049a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An excellent level of enantioselectivity in asymmetric sulfenylation of 4-substituted pyrazolones was achieved with chiral iminophosphorane as the organocatalyst under continuum solvation conditions (up to 99% ee). Importantly, this catalytic process features high efficiency with excellent enantioselectivities, easy separation of products, low catalytic loadings and scale-up to grams without loss of enantioselectivity.
引用
收藏
页码：397 / 400
页数：4
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