Inhibitory effect of Agaricu blazei Murill components on abnormal collagen fiber formation in human hepatocarcinoma cells

被引：7
|
作者：
Sorimachi, Kenji [1 ]
Akimoto, Kazurni [2 ]
Koge, Takashi [3 ]
机构：
[1] Dokkyo Med Univ, Educ Support Ctr, Mibu, Tochigi 3210293, Japan
[2] Dokkyo Med Univ, Clin Med Res Ctr, Mibu, Tochigi 3210293, Japan
[3] BHN Co Ltd, Chiyoda Ku, Tokyo 1010054, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 02期
关键词：
Agaricus blazei Murill; collagen fiber formation; mycelia; human hepatocarcinoma cells; reverse transcription-polymerase chain reaction (RT-PCR);
D O I：
10.1271/bbb.70700
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hot-water extracts of the mycelial culture and fruiting bodies of Agaricus blazei Murill were fractionated by ethanol precipitation, using various ethanol concentrations. The mycelial fraction (A-4) inhibited abnormal collagen fiber formation, and fractions A-1 to A-3 showed a small inhibitory effect. The strongest inhibition was obtained by fraction A-4, and no significant inhibition was observed with fractions A-5 and A-6. With the fruiting bodies, fractions B-I to B-6 showed no inhibitory effects on collagen fiber formation in HCC. The reverse transcription-polymerase chain reaction (RT-PCR) demonstrates that Agaricus blazei mycelial fraction A-4 did not inhibit the type I, II or III procollagen gene expression.
引用
收藏
页码：621 / 623
页数：3
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