Inhibitory effect of Agaricu blazei Murill components on abnormal collagen fiber formation in human hepatocarcinoma cells

被引：7

作者：

Sorimachi, Kenji ^{[1
]}

Akimoto, Kazurni ^{[2
]}

Koge, Takashi ^{[3
]}

机构：

[1] Dokkyo Med Univ, Educ Support Ctr, Mibu, Tochigi 3210293, Japan

[2] Dokkyo Med Univ, Clin Med Res Ctr, Mibu, Tochigi 3210293, Japan

[3] BHN Co Ltd, Chiyoda Ku, Tokyo 1010054, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 02期

关键词：

Agaricus blazei Murill; collagen fiber formation; mycelia; human hepatocarcinoma cells; reverse transcription-polymerase chain reaction (RT-PCR);

D O I：

10.1271/bbb.70700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hot-water extracts of the mycelial culture and fruiting bodies of Agaricus blazei Murill were fractionated by ethanol precipitation, using various ethanol concentrations. The mycelial fraction (A-4) inhibited abnormal collagen fiber formation, and fractions A-1 to A-3 showed a small inhibitory effect. The strongest inhibition was obtained by fraction A-4, and no significant inhibition was observed with fractions A-5 and A-6. With the fruiting bodies, fractions B-I to B-6 showed no inhibitory effects on collagen fiber formation in HCC. The reverse transcription-polymerase chain reaction (RT-PCR) demonstrates that Agaricus blazei mycelial fraction A-4 did not inhibit the type I, II or III procollagen gene expression.

引用

页码：621 / 623

页数：3

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