Existence of a genetic risk factor on chromosome 5q in Italian Coeliac Disease families

被引:61
|
作者
Greco, L
Babron, MC
Corazza, GR
Percopo, S
Sica, R
Clot, F
Fulchignoni-Lataud, MC
Zavattari, P
Momigliano-Richiardi, P
Casari, G
Gasparini, P
Tosi, R
Mantovani, V
De Virgiliis, S
Iacono, G
D'Alfonso, A
Selinger-Leneman, H
Lemainque, A
Serre, JL
Clerget-Darpoux, F
机构
[1] Univ Naples Federico II, Dipartimento Pediat, I-80100 Naples, Italy
[2] INSERM, U155, F-94275 Le Kremlin Bicetre, France
[3] IRCCS S Matteo Hosp, Dept Gastroenterol, Pavia, Italy
[4] Univ Versailles, Lab Cytogenet & Biol Mol Humaine, F-78000 Versailles, France
[5] Univ Turin, Dipartimento Sci Med 2, I-10124 Turin, Italy
[6] Casa Solliero Sofferenza, San Giovanni Rotondo, Italy
[7] CNR, Ist Biol Cellulare, I-00137 Rome, Italy
[8] Osp Suor Orsola Malpighi, Lab Anal, Bologna, Italy
[9] Univ Cagliari, Ist Clin & Biol Eta Evolut Malattie Metab, I-09124 Cagliari, Italy
[10] Univ Palermo, Osped Bambini, Clin Pediat Reparto Biondo, I-90133 Palermo, Italy
[11] Ctr Natl Genotypage, Evry, France
关键词
D O I
10.1046/j.1469-1809.2001.6510035.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Coeliac disease (CD) is a malabsorptive disorder of the small intestine resulting from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the whole genetic susceptibility. Several regions of potential linkage on chromosomes 3q, 5q, 10q 11q, 15q and 19q have already been reported in the literature. These six regions were analyzed with the Maximum Lod Score method on a dense set of markers. A new sample of 89 Italian sibpairs was available for study. There was no evidence for linkage for any of the regions tested, except for chromosome 5q. For this region, our data, as well as a sample of 93 sibpairs from our first genome screen (Greco et al. 1998), are compatible with the presence of a risk factor for CD with a moderate effect.
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页码:35 / 41
页数:7
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