ALK-negative anaplastic large cell lymphoma with "Hodgkin-like" cytomorphology and nuclear expression of PAX5

被引：2
|
作者：
Fratoni, Stefano [1 ]
Niscola, Pasquale [2 ]
Zhao, Xiangfeng Frank [3 ]
Larocca, Luigi Maria [4 ]
Capalbo, Anna [5 ]
Fabbretti, Maria [4 ]
Bernardini, Laura [6 ]
Abruzzese, Elisabetta [2 ]
机构：
[1] St Eugenio Hosp, Dept Surg Pathol Hematopathol, Rome, Italy
[2] St Eugenio Hosp, Hematol Unit, Rome, Italy
[3] Univ Arizona, Coll Med, Phoenix VA Healthcare Syst Pathol & Lab Med Serv, Dept Pathol, Phoenix, AZ USA
[4] Catholic Univ, Dept Surg Pathol, Rome, Italy
[5] Casa Sollievo Sofferenza IRCCS Fdn, Cytogenet Unit, San Giovanni Rotondo, Italy
[6] CSS Mendel Inst, Rome, Italy
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2020年 / 216卷 / 02期
关键词：
ALK-negative anaplastic large cell lymphoma; Hodgkin-like" features; PAX5;
D O I：
10.1016/j.prp.2019.152724
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30 + T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms. We describe an exceptional case of ALK- ALCL with a striking "Hodgkin-like" cytomorphology and a very uncommon nuclear expression of PAX5.
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页数：5
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