ALK-negative anaplastic large cell lymphoma with "Hodgkin-like" cytomorphology and nuclear expression of PAX5

被引：2

作者：

Fratoni, Stefano ^{[1
]}

Niscola, Pasquale ^{[2
]}

Zhao, Xiangfeng Frank ^{[3
]}

Larocca, Luigi Maria ^{[4
]}

Capalbo, Anna ^{[5
]}

Fabbretti, Maria ^{[4
]}

Bernardini, Laura ^{[6
]}

Abruzzese, Elisabetta ^{[2
]}

机构：

[1] St Eugenio Hosp, Dept Surg Pathol Hematopathol, Rome, Italy

[2] St Eugenio Hosp, Hematol Unit, Rome, Italy

[3] Univ Arizona, Coll Med, Phoenix VA Healthcare Syst Pathol & Lab Med Serv, Dept Pathol, Phoenix, AZ USA

[4] Catholic Univ, Dept Surg Pathol, Rome, Italy

[5] Casa Sollievo Sofferenza IRCCS Fdn, Cytogenet Unit, San Giovanni Rotondo, Italy

[6] CSS Mendel Inst, Rome, Italy

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2020年 / 216卷 / 02期

关键词：

ALK-negative anaplastic large cell lymphoma; Hodgkin-like" features; PAX5;

D O I：

10.1016/j.prp.2019.152724

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30 + T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms. We describe an exceptional case of ALK- ALCL with a striking "Hodgkin-like" cytomorphology and a very uncommon nuclear expression of PAX5.

引用

页数：5

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