Klotho in acute kidney injury: biomarker, therapy, or a bit of both?

被引：18

作者：

Aiello, Sistiana ^{[1
]}

Noris, Marina ^{[1
]}

机构：

[1] Mario Negri Inst Pharmacol Res, Transplant Res Ctr, I-24020 Bergamo, Italy

来源：

KIDNEY INTERNATIONAL | 2010年 / 78卷 / 12期

关键词：

REDUCES APOPTOSIS; EXPRESSION;

D O I：

10.1038/ki.2010.367

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute kidney injury (AKI) diagnosis is based on an increase in serum creatinine or a decrease in urine output. To be effective, treatment of AKI should be started very early after the insult and well before the rise of serum creatinine. Thus, sensitive biologic markers of renal tubular injury in AKI are strongly needed. Hu et al. suggest that Klotho could be a novel biomarker and therapeutic target of ischemia-induced AKI. Kidney International (2010) 78, 1208-1210. doi:10.1038/ki.2010.367

引用

页码：1208 / 1210

页数：4

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