Link between Gangliosides, Sphingolipids and Alzheimer's Disease

被引：0
|
作者：
Grimm, M. O. W. [1 ]
Groesgen, S. [1 ]
Hartmann, T. [1 ]
机构：
[1] Univ Saarland, D-6650 Homburg, Germany
来源：
NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2009 | 2009年
关键词：
AMYLOID PRECURSOR PROTEIN; SERINE PALMITOYLTRANSFERASE; INTRAMEMBRANE PROTEOLYSIS; METABOLISM; SECRETASE; BETA;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In the pathological progression of Alzheimer's disease (AD) the deposition of amyloid plaques is mainly due to the aggregation of a peptide, termed Amyloid beta peptide (A beta). Our previous studies(1) suggest that beside this pathological attribute of amyloidogenic APP processing, a physiological function of A beta in regulating sphingolipid homeostasis exists. Here we present a technical approach based on measuring enzyme activity and mass spectrometry profiles to identify possible mechanisms in (glyco-)sphingolipid metabolism linked with AD.
引用
收藏
页码：317 / 320
页数：4
相关论文
共 50 条
  • [31] The link between iron, metabolic syndrome, and Alzheimer’s disease
    Edna Grünblatt
    Jasmin Bartl
    Peter Riederer
    [J]. Journal of Neural Transmission, 2011, 118 : 371 - 379
  • [32] Inflammation as a Possible Link Between Dyslipidemia and Alzheimer's Disease
    de Lima Oliveira, Bruno Cabral
    Quaglio Bellozi, Paula Maria
    Reis, Helton Jose
    Pinheiro de Oliveira, Antonio Carlos
    [J]. NEUROSCIENCE, 2018, 376 : 127 - 141
  • [33] Oxidized LDL: a link between atherosclerosis and Alzheimer's disease?
    Faria, M. C.
    Grossi, M. F.
    Goncalves, G. S.
    Carvalho, M. G.
    Sousa, L. P.
    Silveira, J. N.
    Silva, I. O.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 : 916 - 917
  • [34] Erythrocytes as Potential Link between Diabetes and Alzheimer's Disease
    Carelli-Alinovi, Cristiana
    Misiti, Francesco
    [J]. FRONTIERS IN AGING NEUROSCIENCE, 2017, 9
  • [35] Link between dental amalgam and Alzheimer's disease refuted
    Larkin, M
    [J]. LANCET, 1999, 353 (9153): : 649 - 649
  • [36] Gangliosides determine the amyloid pathology of Alzheimer's disease
    Oikawa, Naoto
    Yamaguchi, Haruyasu
    Ogino, Koichi
    Taki, Takao
    Yuyama, Kohei
    Yamamoto, Naoki
    Shin, Ryong-Woon
    Furukawa, Koichi
    Yanagisawa, Katsuhiko
    [J]. NEUROREPORT, 2009, 20 (12) : 1043 - 1046
  • [37] Alzheimer's peptide: A possible link between glaucoma, exfoliation syndrome and Alzheimer's disease
    Janciauskiene, S
    Krakau, T
    [J]. ACTA OPHTHALMOLOGICA SCANDINAVICA, 2001, 79 (03): : 328 - 329
  • [38] Is there a link between cancer and Alzheimer disease?
    Bennett, David A.
    Leurgans, Sue
    [J]. NEUROLOGY, 2010, 74 (02) : 100 - 101
  • [39] Down syndrome and Alzheimer's disease: A link between development and aging
    Lott, IT
    Head, E
    [J]. MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS, 2001, 7 (03): : 172 - 178
  • [40] Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease
    Plourde, Melanie
    Fortier, Melanie
    Vandal, Milene
    Tremblay-Mercier, Jennifer
    Freemantle, Erika
    Begin, Michel
    Pifferi, Fabien
    Cunnane, Stephen C.
    [J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2007, 77 (5-6): : 301 - 308
12345