Potential roles of insulin and IGF-1 in Alzheimer's disease

被引：223
|
作者：
Gasparini, L
Xu, HX
机构：
[1] Nicox Res Inst, I-20091 Milan, Italy
[2] Rockefeller Univ, Fisher Ctr Res Alzheimer Dis, New York, NY 10021 USA
来源：
TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 08期
关键词：
D O I：
10.1016/S0166-2236(03)00163-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Aging is characterized by a significant decline of metabolic and hormonal functions, which often facilitates the onset of severe age-associated pathologies. One outstanding example of this is the reported association of deranged signaling by insulin and insulin-like-growth-factor 1 (IGF-1) with Alzheimer's disease (AD). Recent compelling biological data reveal effects of insulin and IGF-1 on molecular and cellular mechanisms underlying the pathology of AD. This review discusses available biological data that highlight the therapeutic potential of the insulin-IGF-1 signaling pathway in AD.
引用
下载
收藏
页码：404 / 406
页数：3
相关论文
共 50 条
  • [21] IGF-1 and cardiovascular disease
    Higashi, Yusuke
    Gautam, Sandeep
    Delafontaine, Patrick
    Sukhanov, Sergiy
    GROWTH HORMONE & IGF RESEARCH, 2019, 45 : 6 - 16
  • [22] Human Neural Stem Cells Expressing IGF-1: A Novel Cellular Therapy for Alzheimer's Disease
    McGinley, Lisa M.
    Kashlan, Osama N.
    Chen, Kevin S.
    Backus, Carey
    Pacut, Crystal M.
    Sakowski, Stacey A.
    Johe, Karl
    Feldman, Eva L.
    Kashlan, Osama
    ANNALS OF NEUROLOGY, 2015, 78 : S83 - S83
  • [23] The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons
    Aid, S.
    George, C.
    Gontier, G.
    Lacube, P.
    Francois, J. -C.
    Holzenberger, M.
    JOURNAL OF NEUROCHEMISTRY, 2017, 142 : 206 - 206
  • [24] Uncovering the intricacies of IGF-1 in Alzheimer’s disease: new insights from regulation to therapeutic targeting
    Navpreet Kaur
    Khadga Raj Aran
    Inflammopharmacology, 2025, 33 (3) : 1311 - 1330
  • [25] Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain
    Mueller, Paul L.
    Pritchett, Carolyn E.
    Wiechman, Tyler N.
    Zharikov, Alevtina
    Hajnal, Andras
    BRAIN RESEARCH BULLETIN, 2018, 143 : 27 - 35
  • [26] Studies on insulin/IGF-1 hybrid and IGF-1 growth-promoting functional region
    Wang, P
    Cai, RR
    Feng, YM
    Zhang, YS
    IUBMB LIFE, 2000, 49 (04) : 321 - 325
  • [27] The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons
    George, Caroline
    Gontier, Geraldine
    Lacube, Philippe
    Francois, Jean-Christophe
    Holzenberger, Martin
    Aid, Saba
    BRAIN, 2017, 140 : 2012 - 2027
  • [28] IGF-1: an endogenous link between traumatic brain injury and Alzheimer disease?
    Zheng, Ping
    Tong, Wusong
    JOURNAL OF NEUROSURGICAL SCIENCES, 2017, 61 (04) : 416 - 421
  • [29] Potential Roles of Peroxisomes in Alzheimer's Disease and in Dementia of the Alzheimer's Type
    Lizard, Gerard
    Rouaud, Olivier
    Demarquoy, Jean
    Cherkaoui-Malki, Mustapha
    Iuliano, Luigi
    JOURNAL OF ALZHEIMERS DISEASE, 2012, 29 (02) : 241 - 254
  • [30] INSULIN AND IGF-1 BINDING IN CHICK SCLERA
    WALDBILLIG, RJ
    ARNOLD, DR
    FLETCHER, RT
    CHADER, GJ
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1990, 31 (06) : 1015 - 1022
12345