4-HYDROXY-2-QUINOLONES. 192.* RELATIONSHIP OF STRUCTURE AND ANALGESIC ACTIVITY OF 4-AMINO-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS AND THEIR DERIVATIVES

被引：3

作者：

Ukrainets, I. V. ^{[1
]}

Mospanova, E. V. ^{[2
]}

Davidenko, A. A. ^{[3
]}

Shishkina, S. V. ^{[4
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

[2] Vladimir Dal Eastern Ukrainian Natl Univ, Inst Chem Technol, UA-93003 Rubizhne, Ukraine

[3] NI Pirogov Vinnitsa Natl Med Univ, UA-21018 Vinnitsa, Ukraine

[4] Natl Acad Sci Ukraine, Inst Single Crystals, UA-61001 Kharkov, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 46卷 / 11期

关键词：

4-N-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids; analgesic activity; X-ray diffraction crystallographic structural analysis;

D O I：

10.1007/s10593-011-0674-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some 4-N-R-2-Oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives were synthesized as close structural analogs of the highly-active analgesic 4-benzylamino-2-oxo-1,2-dihydroquinoline-carboxylic acid. Pharmacological testing showed that manifestation of an analgesic effect depends on the presence of a carboxylic group and benzyl fragment in these molecules.

引用

页码：1371 / 1379

页数：9

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