4-HYDROXY-2-QUINOLONES. 192.* RELATIONSHIP OF STRUCTURE AND ANALGESIC ACTIVITY OF 4-AMINO-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS AND THEIR DERIVATIVES

被引：3
|
作者：
Ukrainets, I. V. [1 ]
Mospanova, E. V. [2 ]
Davidenko, A. A. [3 ]
Shishkina, S. V. [4 ]
机构：
[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine
[2] Vladimir Dal Eastern Ukrainian Natl Univ, Inst Chem Technol, UA-93003 Rubizhne, Ukraine
[3] NI Pirogov Vinnitsa Natl Med Univ, UA-21018 Vinnitsa, Ukraine
[4] Natl Acad Sci Ukraine, Inst Single Crystals, UA-61001 Kharkov, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 46卷 / 11期
关键词：
4-N-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids; analgesic activity; X-ray diffraction crystallographic structural analysis;
D O I：
10.1007/s10593-011-0674-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some 4-N-R-2-Oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives were synthesized as close structural analogs of the highly-active analgesic 4-benzylamino-2-oxo-1,2-dihydroquinoline-carboxylic acid. Pharmacological testing showed that manifestation of an analgesic effect depends on the presence of a carboxylic group and benzyl fragment in these molecules.
引用
收藏
页码：1371 / 1379
页数：9
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