Towards specific inhibition of mTORC2

被引:15
|
作者
Murray, Elizabeth R. [1 ]
Cameron, Angus J. M. [1 ]
机构
[1] Queen Mary Univ London, John Vane Sci Ctr, Kinase Biol Lab, Ctr Tumour Biol,Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England
来源
AGING-US | 2017年 / 9卷 / 12期
关键词
mTOR; mTORC2; AGC kinases; AKT; PKC; Sin1; LIFE-SPAN;
D O I
10.18632/aging.101346
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:2461 / 2462
页数:2
相关论文
共 50 条
  • [31] XPLN is a novel regulator of mTORC2
    Khanna, Nidhi
    Fang, Yimin
    Yoon, MeeSup
    Chen, Jie
    FASEB JOURNAL, 2013, 27
  • [32] mTORC1 and mTORC2 in cancer and the tumor microenvironment
    L C Kim
    R S Cook
    J Chen
    Oncogene, 2017, 36 : 2191 - 2201
  • [33] REGULATION AND METABOLIC FUNCTIONS OF mTORC1 AND mTORC2
    Szwed, Angelia
    Kim, Eugene
    Jacinto, Estela
    PHYSIOLOGICAL REVIEWS, 2021, 101 (03) : 1371 - 1426
  • [34] mTORC1 and mTORC2 in cancer and the tumor microenvironment
    Kim, L. C.
    Cook, R. S.
    Chen, J.
    ONCOGENE, 2017, 36 (16) : 2191 - 2201
  • [35] mTORC2 contributes to systemic autoimmunity
    Zhou, Xian
    Qi, Haiyu
    Li, Meilu
    Li, Yanfeng
    Zhu, Xingxing
    Amin, Shreyasee
    Alexander, Mariam
    Diadhiou, Catherine
    Davidson, Anne
    Zeng, Hu
    IMMUNOLOGY, 2023, 168 (03) : 554 - 568
  • [36] MTORC2 brings up the rear
    Rachel David
    Nature Reviews Molecular Cell Biology, 2011, 12 : 74 - 75
  • [37] XPLN is an endogenous inhibitor of mTORC2
    Khanna, Nidhi
    Fang, Yimin
    Yoon, Mee-Sup
    Chen, Jie
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (40) : 15979 - 15984
  • [38] Therapeutic Targeting of mTORC2 in mTORopathies
    Dentel, Brianne
    Escamilla, Christine Ochoa
    Tsai, Peter T.
    NEURON, 2019, 104 (06) : 1032 - 1033
  • [39] mTORC1/mTORC2 SIGNALING IN PILOCYTIC ASTROCYTOMA
    Hutt, Marianne
    Karajannis, Matthias A.
    Shah, Smit
    Eberhart, Charles G.
    Raabe, Eric
    Rodriguez, Fausto J.
    NEURO-ONCOLOGY, 2013, 15 : 48 - 48
  • [40] mTORC2 caught in a SINful Akt
    Polak, Pazit
    Hall, Michael N.
    DEVELOPMENTAL CELL, 2006, 11 (04) : 433 - 434