A new role for CD23 in inflammation

被引：59
|
作者：
Bonnefoy, JY
PlaterZyberk, C
LecoanetHenchoz, S
Gauchat, JF
Aubry, JP
Graber, P
机构：
来源：
IMMUNOLOGY TODAY | 1996年 / 17卷 / 09期
关键词：
D O I：
10.1016/0167-5699(96)10054-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD23, is expressed on a variety of haematopoietic cell types and displays pleiotropic activities in vitro. Here Jean-Yves Bonnefoy and collegues discuss a novel interaction between CD23 and the alpha chains of the beta(2) integrins, CD11b and CD11c, that leads to a proinflammatory pattern of macrophage activation. They describe how neutralizing antibodies to CD23 can decrease the severity of murine arthritis.
引用
收藏
页码：418 / 420
页数：3
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